Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.

@article{Monk2012Th17CA,
  title={Th17 cell accumulation is decreased during chronic experimental colitis by (n-3) PUFA in Fat-1 mice.},
  author={Jennifer M. Monk and Qian Jia and Evelyn S. Callaway and Brad R. Weeks and Robert C. Alaniz and David N. McMurray and Robert S. Chapkin},
  journal={The Journal of nutrition},
  year={2012},
  volume={142 1},
  pages={
          117-24
        }
}
During colon inflammation, Th17 cells and immunosuppressive regulatory T cells (Treg) are thought to play promotive and preventative roles, respectively. Dietary (n-3) PUFA favorably modulate intestinal inflammation in part by downregulating T-cell activation and functionality. We used the Fat-1 mouse, a genetic model that synthesizes long-chain (n-3) PUFA de novo, to test the hypothesis that (n-3) PUFA protect against colonic inflammation by modulating the polarization of Treg and Th17 cells… CONTINUE READING

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