Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients

@article{Karlsson2000Th1likeDI,
  title={Th1-like dominance in high-risk first-degree relatives of Type I diabetic patients},
  author={M. G. E. Karlsson and S. Sederholm Lawesson and Johnny Ludvigsson},
  journal={Diabetologia},
  year={2000},
  volume={43},
  pages={742-749}
}
Aims/hypothesis. The humoral part of the immune system, including autoantibodies, is known to predict manifest Type I (insulin-dependent) diabetes mellitus in first-degree relatives but the cell-mediated immune process preceding the manifest disease still is not known. The aim of this investigation was to estimate the immunological balance of Th-like lymphocytes (Th1/Th2) in high-risk first-degree relatives of Type I diabetic children.¶Methods. Peripheral blood mononuclear cells (PBMC) from 21… CONTINUE READING

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