Th1 cell-mediated resistance to cutaneous infection with Leishmania major is independent of P- and E-selectins.

@article{Zaph2003Th1CR,
  title={Th1 cell-mediated resistance to cutaneous infection with Leishmania major is independent of P- and E-selectins.},
  author={Colby Zaph and Phillip Scott},
  journal={Journal of immunology},
  year={2003},
  volume={171 9},
  pages={4726-32}
}
Studies in several models of inflammation have underscored the importance of P- and E-selectins in the migration of T cells to inflamed tissues. However, the role of the endothelial selectins in infection-induced cutaneous inflammation and host-protective immunity has not been investigated. In this study, we demonstrate that CD4(+) T cells recruited to the cutaneous compartment during infection with Leishmania major express P- and E-selectin ligands. Furthermore, expression of P- and E-selectin… CONTINUE READING
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