Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-alpha.

@article{Feng2004Th1Th2BA,
  title={Th1/Th2 balance and HTLV-I proviral load in HAM/TSP patients treated with interferon-alpha.},
  author={Juan Feng and T. M. Misu and Kazuo Fujihara and Naoko Misawa and Yoshio Koyanagi and Yusei Shiga and Atsushi Takeda and Shigeru Sato and Sadao Takase and Takeshi Kohnosu and Hiroshi Saito and Y. Itoyama},
  journal={Journal of neuroimmunology},
  year={2004},
  volume={151 1-2},
  pages={189-94}
}
We studied the immunological and virological effects of interferon-alpha (IFN-alpha) therapy in nine patients with HTLV-I-associated myelopathy (HAM/TSP). After therapy, the percentages of CCR5+ cells in CD4+ cells significantly decreased in the cerebrospinal fluid as well as blood. The therapy also significantly lowered the intracellular IFN-gamma+/interleukin-4+ T-cell ratio in blood. Those helper T-cell type 1 (Th1)-related responses tended to be higher and reduce more evidently following… CONTINUE READING