Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.

@article{Stummvoll2008Th1TA,
  title={Th1, Th2, and Th17 effector T cell-induced autoimmune gastritis differs in pathological pattern and in susceptibility to suppression by regulatory T cells.},
  author={Georg H. Stummvoll and Richard J Dipaolo and Eva N. Huter and Todd Scott Davidson and Deborah D Glass and Jerrold M Ward and Ethan M Shevach},
  journal={Journal of immunology},
  year={2008},
  volume={181 3},
  pages={1908-16}
}
Th cells can be subdivided into IFN-gamma-secreting Th1, IL-4/IL-5-secreting Th2, and IL-17-secreting Th17 cells. We have evaluated the capacity of fully differentiated Th1, Th2, and Th17 cells derived from a mouse bearing a transgenic TCR specific for the gastric parietal cell antigen, H(+)K(+)-ATPase, to induce autoimmune gastritis after transfer to immunodeficient recipients. We have also determined the susceptibility of the disease induced by each of the effector T cell types to suppression… CONTINUE READING
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