Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.

@article{Teitz2013ThMYCNMW,
  title={Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.},
  author={Tal Teitz and Madoka Inoue and Marcus B. Valentine and Kejin Zhu and Jerold E. Rehg and Wei Zhao and David Finkelstein and Yong-Dong Wang and Melissa D. Johnson and Christopher J. Calabrese and Marcelo Rubinstein and Razqallah Hakem and William S. Weiss and Jill M. Lahti},
  journal={Cancer research},
  year={2013},
  volume={73 13},
  pages={4086-97}
}
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow. Advances in therapy and understanding of the metastatic process have been limited due, in part, to the lack of animal models harboring bone marrow disease. The widely used transgenic model, the Th-MYCN mouse, exhibits limited metastasis to this site. Here, we establish the… CONTINUE READING
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