Th 2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas

@inproceedings{Shimizu2004Th2I,
  title={Th 2-predominant inflammation and blockade of IFN-γ signaling induce aneurysms in allografted aortas},
  author={Koichi Shimizu and Masayoshi Shichiri and P. Scott Libby and Richard T Lee and Richard J. Mitchell},
  year={2004}
}
Abdominal aortic aneurysms (AAAs) cause death due to complications related to expansion and rupture. The underlying mechanisms that drive AAA development remain largely unknown. We recently described evidence for a shift toward T helper type 2 (Th2) cell responses in human AAAs compared with stenotic atheromas. To evaluate putative pathways in AAA formation, we induced Th1or Th2-predominant cytokine environments in an inflammatory aortic lesion using murine aortic transplantation into WT hosts… CONTINUE READING
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Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysms

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