Tgf-Beta pathway as a therapeutic target in bone metastases.


Breast and prostate cancer frequently metastasizes to the skeleton and causes bone destruction. In skeletal tissue, transforming growth factor-beta (TGF-beta) is a major bone-derived factor responsible for driving a feed-forward vicious cycle of breast cancer growth in bone. TGF-beta is released from bone in active form by osteoclastic resorption and… (More)


Cite this paper

@article{Jurez2010TgfBetaPA, title={Tgf-Beta pathway as a therapeutic target in bone metastases.}, author={Patricia M Ju{\'a}rez and Theresa A. Guise}, journal={Current pharmaceutical design}, year={2010}, volume={16 11}, pages={1301-12} }