Tgat, a Rho-specific guanine nucleotide exchange factor, activates NF-kappaB via physical association with IkappaB kinase complexes.

@article{Yamada2007TgatAR,
  title={Tgat, a Rho-specific guanine nucleotide exchange factor, activates NF-kappaB via physical association with IkappaB kinase complexes.},
  author={Kenji Yamada and Ryozo Moriuchi and Tsuyoshi Mori and Eiko Okazaki and Tomoko Kohno and Takeshi Nagayasu and Toshifumi Matsuyama and Shigeru Katamine},
  journal={Biochemical and biophysical research communications},
  year={2007},
  volume={355 1},
  pages={269-74}
}
Constitutive activity of NF-kappaB is associated with various human cancers including adult T-cell leukemia (ATL). In this study, we have found Tgat that activates NF-kappaB by screening a cDNA expression library derived from ATL cells. We previously identified Tgat as the oncogene, which consists of the Rho-guanine nucleotide exchange factor (Rho-GEF) domain and the unique C-terminal region, as a consequence of alternative splicing of the Trio transcript. Tgat activated the IKK activity by… CONTINUE READING