Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans?

Abstract

Although rare, uveal melanoma (UM) is the most common primary intraocular tumor in adults. About half of UM patients develop metastatic disease typically in the liver and die within a short period, due to ineffective systemic therapies. UM has unique and distinct genetic features predictive of metastasis. Animal models are required to improve our… (More)
DOI: 10.1016/j.exer.2014.07.009

Cite this paper

@article{Schiffner2014TgGrm1TM, title={Tg(Grm1) transgenic mice: a murine model that mimics spontaneous uveal melanoma in humans?}, author={Susanne Schiffner and Barbara M. Braunger and Miriam M de Jel and Sarah E Coupland and Ernst R Tamm and Anja K Bosserhoff}, journal={Experimental eye research}, year={2014}, volume={127}, pages={59-68} }