TfOH-catalyzed intramolecular alkyne-ketone metathesis leading to highly substituted five-membered cyclic enones.


The intramolecular carbocyclization of tethered alkynyl ketones to five-membered cyclic enones is shown to be catalyzed by trifluoromethanesulfonic acid in MeOH, proceeding in good to excellent yields and with high selectivities. 
DOI: 10.1039/b905954g


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