Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.

@article{MenziesGow2021TezepelumabIA,
  title={Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.},
  author={Andrew Menzies-Gow and Jonathan Corren and Arnaud Bourdin and Geoffrey Lowell Chupp and Elliot Israel and Michael E. Wechsler and Christopher E. Brightling and Janet M. Griffiths and {\AA}sa Hellqvist and Karin Bowen and Primal P. Kaur and Gun Almqvist and Sandhia Ponnarambil and Gene L. Colice},
  journal={The New England journal of medicine},
  year={2021},
  volume={384 19},
  pages={
          1800-1809
        }
}
BACKGROUND Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma require further assessment. METHODS We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled trial. Patients (12 to 80 years of age) were randomly assigned to receive tezepelumab (210 mg) or placebo subcutaneously… 
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