Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.
@article{MenziesGow2021TezepelumabIA, title={Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma.}, author={Andrew Menzies-Gow and Jonathan Corren and Arnaud Bourdin and Geoffrey Lowell Chupp and Elliot Israel and Michael E. Wechsler and Christopher E. Brightling and Janet M. Griffiths and {\AA}sa Hellqvist and Karin Bowen and Primal P. Kaur and Gun Almqvist and Sandhia Ponnarambil and Gene L. Colice}, journal={The New England journal of medicine}, year={2021}, volume={384 19}, pages={ 1800-1809 } }
BACKGROUND
Tezepelumab is a human monoclonal antibody that blocks thymic stromal lymphopoietin, an epithelial-cell-derived cytokine implicated in the pathogenesis of asthma. The efficacy and safety of tezepelumab in patients with severe, uncontrolled asthma require further assessment.
METHODS
We conducted a phase 3, multicenter, randomized, double-blind, placebo-controlled trial. Patients (12 to 80 years of age) were randomly assigned to receive tezepelumab (210 mg) or placebo subcutaneously…
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