Tetronothiodin, a novel CCKB receptor ligand, antagonizes cholecystokinin-induced Ca2+ mobilization in a pituitary cell line.

@article{Kuwahara1992TetronothiodinAN,
  title={Tetronothiodin, a novel CCKB receptor ligand, antagonizes cholecystokinin-induced Ca2+ mobilization in a pituitary cell line.},
  author={Tomohiro Kuwahara and Takashi Kudoh and Hiroshi Nagase and Masayuki Takamiya and Akinobu Nakano and Toshiaki Ohtsuka and Hiroshi Yoshizaki and Munehisa Arisawa},
  journal={European journal of pharmacology},
  year={1992},
  volume={221 1},
  pages={99-105}
}
We found a novel nonpeptide CCKB receptor antagonist, tetronothiodin (Ro 09-1468), in the culture broth of Streptomyces sp. NR0489. The structure of the compound (C31O8H38S), which has a 19-membered ring with an alpha-acyltetronic acid and tetrahydrothiophene moiety, is completely different from that of any known CCK receptor antagonist. Tetronothiodin… CONTINUE READING