Tetrodotoxin-producing bacteria from the blue-ringed octopus Octopus maculosus

  title={Tetrodotoxin-producing bacteria from the blue-ringed octopus Octopus maculosus},
  author={Deng Fwu Hwang and Osamu Arakawa and T. Sait{\^o} and Tamao Noguchi and Usio Simidu and Kumiko Tsukamoto and Yasuo Shida and Kanehisa Hashimoto},
  journal={Marine Biology},
Several live specimens of the blue-ringed octopus Octopus maculosus were collected from the Philippines in November 1985, and from Japan in February 1986, and the distribution of toxicity, along with toxin composition, in the posterior salivary gland and other soft parts were examined. Tetrodotoxin (TTX: 1400 mouse units g-1) was detected in the posterior salivary gland of a Japanese specimen, while not only the salivary gland but other soft parts were toxic in the Philippine specimens. The… 

Seasonal characteristics and tetrodotoxin-producing ability of bacteria in gastropod Oliva hirasei

The results showed that Vibrio, Pseudomonas, and Shewanella certainly produced TTX, and the total bacterial counts in the March samples were higher than those in the August samples, but the amount of toxin showed an inverted pattern.

Tetrodotoxin-producing Bacillus sp. from the ribbon worm (Nemertea) Cephalothrix simula (Iwata, 1952).

Intra-organismal distribution of tetrodotoxin in two species of blue-ringed octopuses (Hapalochlaena fasciata and H. lunulata).

Intracellular Immunohistochemical Detection of Tetrodotoxin in Pleurobranchaea maculata (Gastropoda) and Stylochoplana sp. (Turbellaria)

Data suggest that TTX has a defensive function in adult P. maculata, who then invest this in their progeny for protection, and localization in the digestive tissue of P.maculata potentially indicates a dietary source of TTX.

Microflora and Tetrodotoxin-producing Bacteria in the Lined Moon Shell Natica lineata.

The lined moon shell Natica lineata was seasonally collected from two places in Taiwan, Kaohsiung City, and Pintgung Prefecture, and assayed for anatomical distribution of tetrodotoxin (TTX) and

Microflora and tetrodotoxin-producing bacteria in a gastropod, Niotha clathrata.

  • C. A. ChengD. Hwang K. Hasimoto
  • Environmental Science
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 1995

No Evidence for a Culturable Bacterial Tetrodotoxin Producer in Pleurobranchaea maculata (Gastropoda: Pleurobranchidae) and Stylochoplana sp. (Platyhelminthes: Polycladida)

No C9 base or TTX was detected in isolates or broth experiments (past day 0), suggesting a culturable microbial source of TTX in P. maculata and Stylochoplana sp.

Bacterial production of tetrodotoxin in the pufferfish Arothron hispidus

Vibrio harveyi strains isolated from the skin slime and kidneys of A. hispidus were found to produce TTX, being the source of TTX produced in the pufferfish.



Tetrodotoxin-producing bacteria from the horseshoe crab Carcinoscorpius rotundicauda.

The strain which produced TTX and anh-TTX, one of TTX-containing marine invertebrates, was identified as Vibrio alginolyticus on the basis of biochemical and other characters.

Vibrio alginolyticus, a tetrodotoxin-producing bacterium, in the intestines of the fish Fugu vermicularis vermicularis

The findings suggest that some strains of V. alginolyticus are closely related to the toxification of the puffer, and probably of other species.

Occurrence of tetrodotoxin and anhydrotetrodotoxin in Vibrio sp. isolated from the intestines of a xanthid crab, Atergatis floridus.

Results showed the production of TTX and anhydroTTX in the Vibrio sp.

Tetrodotoxin and tetrodotoxin-like compounds from the eggs of the Costa Rican frog, Atelopus chiriquiensis.

Occurrence of a tetrodotoxin-like compound in the eggs of the venomous blue-ringed octopus (Hapalochlaena maculosa).

Maculotoxin: a neurotoxin from the venom glands of the octopus Hapalochlaena maculosa identified as tetrodotoxin.

This is the first reported case in which tetrodotoxin has been found to occur in a venom, and a potent neurotoxin isolated from the posterior salivary glands of the blue-ringed octopus is identified.

Habitat Segregation and Biochemical Activities of Marine Members of the Family Vibrionaceae

A comparative study of marine members of the family Vibrionaceae with the technique of numerical taxonomy revealed habitat segregation as well as a cosmopolitan nature of species distribution among

Pharmacological effects of the venom of the common octopus Hapalochlaena maculosa.

  • E. Trethewie
  • Medicine, Biology
    Toxicon : official journal of the International Society on Toxinology
  • 1965

トゲモミジガイ(ヒトデ)から分離したVibrio alginolyticusによるテトロドトキシンの産生

Intestines of a starfish Astropecten polyacanthus were examined for microflora, it was concluded that these strains, especially the two V. alginolyticus strains, could closely be involved in toxification of the starfish.