Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase.

@article{Koga1999TetratricopeptideR,
  title={Tetratricopeptide repeat (TPR) motifs of p67(phox) participate in interaction with the small GTPase Rac and activation of the phagocyte NADPH oxidase.},
  author={Hanako Koga and Hiroaki Terasawa and Hiroyuki Nunoi and Koichiro Takeshige and Fuyuhiko Inagaki and Hideki Sumimoto},
  journal={The Journal of biological chemistry},
  year={1999},
  volume={274 35},
  pages={
          25051-60
        }
}
The small GTPase Rac functions as a molecular switch in several important cellular events including cytoskeletal reorganization and activation of the phagocyte NADPH oxidase, the latter of which leads to production of superoxide, a precursor of microbicidal oxidants. During formation of the active oxidase complex at the membrane, the GTP-bound Rac appears to interact with the N-terminal region of p67(phox), another indispensable activator that translocates from the cytosol upon phagocyte… CONTINUE READING

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