Tetrathiomolybdate induces doxorubicin sensitivity in resistant tumor cell lines.

Abstract

OBJECTIVE Doxorubicin is a potent anti-cancer agent with efficacy against a broad range of tumors, including endometrial cancer. Doxorubicin produces reactive oxygen species (ROS) resulting in cytotoxicity. Tetrathiomolybdate (TM), a copper-chelating agent, is known to target a cellular antioxidant enzyme copper/zinc-superoxide dismutase. This study tests… (More)
DOI: 10.1016/j.ygyno.2011.03.035

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