Tetrasubstituted furans by Pd(II)-catalyzed three-component domino reactions of 2-(1-alkynyl)-2-alken-1-ones with nucleophiles and vinyl ketones or acrolein.


Transition-metal-catalyzed multicomponent domino reactions, which can provide rapid access to architecturally complex molecules from relatively simple starting materials, are highly important in synthetic chemistry. Highly substituted furans are frequently found as subunits in many bioactive natural products and man-made drugs, and they are also important… (More)
DOI: 10.1002/chem.200901386


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