Tetraspanins: push and pull in suppressing and promoting metastasis

@article{Zller2009TetraspaninsPA,
  title={Tetraspanins: push and pull in suppressing and promoting metastasis},
  author={M. Z{\"o}ller},
  journal={Nature Reviews Cancer},
  year={2009},
  volume={9},
  pages={40-55}
}
  • M. Zöller
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Cancer
Tumours progress through a cascade of events that enable the formation of metastases. Some of the components that are required for this fatal process are well established. Tetraspanins, however, have only recently received attention as both metastasis suppressors and metastasis promoters. This late appreciation is probably due to their capacity to associate with various molecules, which they recruit into special membrane microdomains, and their abundant presence in tumour-derived small vesicles… Expand
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References

SHOWING 1-10 OF 158 REFERENCES
KAI1 tetraspanin and metastasis suppressor.
TLDR
KAI1 is a widely expressed transmembrane glycoprotein of the tetraspanin family that is associated with the advanced stages of many human malignancies and results in the acquisition of invasive and metastatic capabilities by tumour cells, yet the underlying mechanisms responsible for down-regulation of KAI1 expression remain to be resolved. Expand
p130Cas: a versatile scaffold in signaling networks.
TLDR
Recent developments that highlight a fundamental role in cell transformation and microbial pathogenesis and the implications of these developments on p130Cas function under normal and pathological conditions are discussed. Expand
GPR56 and TG2: Possible Roles in Suppression of Tumor Growth by the Microenvironment
TLDR
A ligand that interacts with GPR56 in the extracellular matrix as TG2, a major crosslinking enzyme in the matrix, which has been implicated in suppression of tumor progression; therefore TG2 might serve as a host defense against the invading metastatic cells. Expand
Tetraspanin functions and associated microdomains
  • M. Hemler
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 2005
TLDR
Important new genetic evidence has now emerged, and is bolstered by new insights into the cell biology, signalling and biochemistry of tetraspanins, that provide a framework for better understanding of these mysterious molecules in the regulation of cellular processes. Expand
CD82 metastasis suppressor gene: a potential target for new therapeutics?
TLDR
The diverse array of functions of CD 82, the complexity of the regulation of CD82 and the prospects for targeting CD82 as a therapeutic approach for the treatment of a variety of metastatic cancers are discussed. Expand
Itinerant exosomes: emerging roles in cell and tissue polarity.
TLDR
New evidence is discussed suggesting that exosomes participate in the transport of morphogens and RNA, and thus influence cell polarity and developmental patterning of tissues. Expand
Tetraspanin CD81-regulated cell motility plays a critical role in intrahepatic metastasis of hepatocellular carcinoma.
TLDR
Findings indicate that CD81 functions as a molecular organizer of membrane microdomains, whereby proteins such as PI4KII control actin remodeling and cell motility, establishing a role for these genes as negative modifiers of oncogenicity and HCC progression. Expand
KAI1/CD82, a tumor metastasis suppressor.
TLDR
The loss of KAI1/CD82 expression in invasive and metastatic cancers is due to a complex, epigenetic mechanism that probably involves transcription factors such as NFkappaB, p53, and beta-catenin. Expand
Gastrointestinal tumors: metastasis and tetraspanins.
  • M. Zöller
  • Biology, Medicine
  • Zeitschrift fur Gastroenterologie
  • 2006
TLDR
This review will first provide a brief outline on the currently most accepted view of tumor progression and then discuss whether and how the rather new family of tetraspanin molecules might contribute to cancer progression. Expand
The tetraspanin web modulates immune-signalling complexes
TLDR
The tetraspanin web represents a new concept of molecular interactions in the immune system that tends to associate with each other, together with their partners, in membrane microdomains that provide a scaffold for the transmission of external stimuli to intracellular-signalling components. Expand
...
1
2
3
4
5
...