Tetraspanins: gateways for infection.

  title={Tetraspanins: gateways for infection.},
  author={Peter N Monk and Lynda J. Partridge},
  journal={Infectious disorders drug targets},
  volume={12 1},
The tetraspanins constitute a conserved superfamily of four-span membrane proteins that are widely distributed in multi-cellular organisms. A characteristic property of tetraspanins is their ability to form lateral associations with one another and with other membrane proteins, giving rise to tetraspanin enriched microdomains (TEM) that are involved in the molecular organisation of many membrane-associated functions such as adhesion, fusion and trafficking. Increasing evidence suggests that… CONTINUE READING