Tetraspanin functions and associated microdomains

  title={Tetraspanin functions and associated microdomains},
  author={M. Hemler},
  journal={Nature Reviews Molecular Cell Biology},
  • M. Hemler
  • Published 2005
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • Cell-surface proteins of the tetraspanin family are small, and often hidden by a canopy of tall glycoprotein neighbours in the cell membrane. Consequently, tetraspanins have been understudied and underappreciated, despite their presence on nearly all cell and tissue types. Important new genetic evidence has now emerged, and is bolstered by new insights into the cell biology, signalling and biochemistry of tetraspanins. These new findings provide a framework for better understanding of these… CONTINUE READING
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