Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells

@article{Hong2005TetraspaninCI,
  title={Tetraspanin CD9 induces MMP-2 expression by activating p38 MAPK, JNK and c-Jun pathways in human melanoma cells},
  author={In-Kee Hong and Y. -B. Kim and Doo-il Jeoung and Keun-Cheol Kim and Hansoo Lee},
  journal={Experimental & Molecular Medicine},
  year={2005},
  volume={37},
  pages={230-239}
}
Expression of matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9), which correlates with tumor invasion and metastasis, has been known to be regulated by several intracellular signaling pathways. Since the CD9 membrane protein has been implicated in signal transduction and malignant progression of cancer cells, we examined the functional involvement of CD9 in the regulation of MMP-2 and MMP-9 expression by using stable CD9 transfectant clones of MelJuso human melanoma cells. The CD9 cDNA… CONTINUE READING

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Direct binding of the ligand PSG 17 to CD 9 requires a CD 9 site essential for spermegg fusion

  • DA Ellerman, C Ha, P Primakoff, DG Myles, GS Dveksler
  • Mol Biol Cell
  • 2004

Suppression of cell motility and metastasis by transfection with human motilityrelated protein ( MRP1 / CD 9 ) DNA

  • S Ikeyama, M Koyama, M Yamaoko, R Sasada, M Miyake
  • J Exp Med
  • 2004

Invasive phenotype of MCF 10 A cells overexpressing cHaras and cerbB2 oncogenes

  • D Giunciuglio, M Culty, +7 authors EW Thompson
  • Int J Cancer
  • 2003

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