Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.

@article{Gartlan2013TetraspaninCC,
  title={Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration.},
  author={Kate H Gartlan and Janet L. Wee and Maria C Demaria and Roza Nastovska and Tsz Man Chang and Eleanor Livingston Jones and Vasso Apostolopoulos and Geoffrey A. Pietersz and Michael J Hickey and Annemiek B van Spriel and Mark D Wright},
  journal={European journal of immunology},
  year={2013},
  volume={43 5},
  pages={1208-19}
}
Previous studies on the role of the tetraspanin CD37 in cellular immunity appear contradictory. In vitro approaches indicate a negative regulatory role, whereas in vivo studies suggest that CD37 is necessary for optimal cellular responses. To resolve this discrepancy, we studied the adaptive cellular immune responses of CD37(-/-) mice to intradermal challenge with either tumors or model antigens and found that CD37 is essential for optimal cell-mediated immunity. We provide evidence that an… CONTINUE READING