Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between β1 integrins and small GTPases.

@article{Hong2012TetraspaninCS,
  title={Tetraspanin CD151 stimulates adhesion-dependent activation of Ras, Rac, and Cdc42 by facilitating molecular association between β1 integrins and small GTPases.},
  author={In-Kee Hong and Doo-il Jeoung and Kwon-Soo Ha and Young Myeong Kim and Hansoo Lee},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 38},
  pages={
          32027-39
        }
}
Tetraspanin CD151 associates with laminin-binding α(3)β(1)/α(6)β(1) integrins in epithelial cells and regulates adhesion-dependent signaling events. We found here that CD151 plays a role in recruiting Ras, Rac1, and Cdc42, but not Rho, to the cell membrane region, leading to the formation of α(3)β(1)/α(6)β(1) integrin-CD151-GTPases complexes. Furthermore, cell adhesion to laminin enhanced CD151 association with β(1) integrin and, thereby, increased complex formation between the β(1) family of… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

andRubinstein, E. (2001)Tetraspanins.CellMol

C. Boucheix
  • Life Sci.58,
  • 2001
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

andRubinstein, E. (2001)Tetraspanins.CellMol

C. Boucheix
  • Life Sci.58,
  • 2001
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL