Tetrasomy 8 in a patient with chronic lymphocytic leukemia.

  title={Tetrasomy 8 in a patient with chronic lymphocytic leukemia.},
  author={F{\'a}bio Morato de Oliveira and Renata Amorim Brand{\~a}o and Sabrina Dias Leite-Cueva and Francisco de Paula Careta and Belinda Pinto Sim{\~o}es and Eduardo M Rego and Roberto Passetto Falc{\~a}o},
  journal={Cancer genetics and cytogenetics},
  volume={198 2},
We report a case of a 47-year-old man diagnosed with chronic lymphocytic leukemia (CLL) with two extra copies of chromosome 8. Classical cytogenetic analysis by the immunostimulatory combination of DSP30 and interleukin 2 showed tetrasomy of chromosome 8 in 60% of the metaphase cells (48,XY,+8,+8[12]/46,XY[8]). Spectral karyotype analysis confirmed the abnormality previously seen by G banding. Additionally, interphase fluorescence in situ hybridization using an LSI CEP 8 probe performed on… CONTINUE READING