Tetrapeptides, as small-sized peptidic inhibitors; synthesis and their inhibitory activity against BACE1.


Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is known to be involved in the production of amyloid beta-peptide in Alzheimer's disease and is a major target for current drug design. We previously reported substrate-based peptidomimetics, KMI-compounds as potent BACE1 inhibitors. In this study, we designed and synthesized tetrapeptides as low… (More)
DOI: 10.1002/psc.1238


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