Tetranucleotide microsatellite instability in surgical margins for prediction of local recurrence of head and neck squamous cell carcinoma.

@article{Tmam2004TetranucleotideMI,
  title={Tetranucleotide microsatellite instability in surgical margins for prediction of local recurrence of head and neck squamous cell carcinoma.},
  author={St{\'e}phane T{\'e}mam and Odile Casiraghi and J B Lahaye and Jacques Bosq and Xian Zhou and Morbize Juli{\'e}ron and G{\'e}rard Mamelle and J Jack Lee and Li Mao and Bernard Luboinski and Jean B{\'e}nard and François Janot},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 12 Pt 1},
  pages={4022-8}
}
PURPOSE Postoperative radiotherapy is used to prevent local recurrence of head and neck squamous cell carcinoma in patients with positive surgical margins. We sought to determine whether tetranucleotide microsatellite instability could be detected in surgical margins and used to predict local recurrence. EXPERIMENTAL DESIGN We prospectively collected tumor and surgical margin specimens from patients with head and neck squamous cell carcinoma who had undergone surgical resection at Institut… CONTINUE READING