Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway.

@article{Yan2006TetrandrineinducedAI,
  title={Tetrandrine-induced apoptosis in rat primary hepatocytes is initiated from mitochondria: caspases and endonuclease G (Endo G) pathway.},
  author={Cai Hong Yan and Qi Xin-Ming and Gong Li-Kun and Liu Lin-lin and Chen Fang-Ping and Xiao Yan Ying and Wu Xiong-Fei and Li Xiang-Hong and Ren Jin},
  journal={Toxicology},
  year={2006},
  volume={218 1},
  pages={1-12}
}
Tetrandrine, a bisbenylisoquinoline alkaloid isolated from the dried root of Stephenia tetrandra (S Moore), possesses a remarkable pharmacological profile. However, the mechanisms of tetrandrine hepatotoxicity remain to be elucidated. In this study, we first proved apoptosis and mitochondrial dysfunction induced by tetrandrine in Sprague-Dawley rat liver in vivo. By further assuming apoptosis as an important mechanism in tetrandrine-induced hepatotoxicity, we focused on mitochondria-initiated… CONTINUE READING
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