Tetramolecular quadruplex stability and assembly.

  title={Tetramolecular quadruplex stability and assembly.},
  author={Phong Lan Thao Tran and Anne De Cian and Julien Gros and Rui Moriyama and Jean-Louis Mergny},
  journal={Topics in current chemistry},
Guanine quadruplexes (G4) are unusual four-stranded nucleic acid structures formed by G-rich DNA/RNA. Beyond their likely biological relevance, the self-assembly, stability, and rigidity of these structures are also interesting for nanotechnology and biotechnology applications. Therefore, efforts are carried out to understand the rules that govern stability and folding of G-quadruplexes. We focus this chapter on tetramolecular conformations which are simple tractable models. We report here the… CONTINUE READING

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