Tetramethylpyrazine inhibits angiotensin II-induced cardiomyocyte hypertrophy and tumor necrosis factor-α secretion through an NF-κB-dependent mechanism.

@article{Yu2013TetramethylpyrazineIA,
  title={Tetramethylpyrazine inhibits angiotensin II-induced cardiomyocyte hypertrophy and tumor necrosis factor-α secretion through an NF-κB-dependent mechanism.},
  author={Liangzhu Yu and Tonghui She and Mincai Li and Chunrong Shi and Lu Han and Menglin Cheng},
  journal={International journal of molecular medicine},
  year={2013},
  volume={32 3},
  pages={717-22}
}
Tetramethylpyrazine (TMP), a bioactive compound isolated from the Chinese herb, Ligusticum wallichii Franchat, has been reported to play a protective role in cardiac diseases. However, the cellular and molecular mechanisms behind the protective effects of TMP on the heart remain to be elucidated. In this study, we aimed to determine the effects of TMP on… CONTINUE READING