Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.

@article{Fu2008TetramethylpyrazineIA,
  title={Tetramethylpyrazine inhibits activities of glioma cells and glutamate neuro-excitotoxicity: potential therapeutic application for treatment of gliomas.},
  author={Y M Fu and Yen-Yang Lin and Shih-Chich Chou and Tung-Hu Tsai and Lung-Sen Kao and Shao-Yun Hsu and Fu-chou Cheng and Yang-Hsin Shih and Henrich Cheng and Yu-Yi Fu and J Wang},
  journal={Neuro-oncology},
  year={2008},
  volume={10 2},
  pages={139-52}
}
We tested the herbal extract 2,3,5,6-tetramethylpyrazine (TMP) for possible therapeutic efficacy against a glioma cell line and against gliomas transplanted into rat brains. In the cultured glioma cells, 50 muM TMP significantly inhibited glutamate-induced increase in intracellular calcium. Significant cell damage (30%) and proliferation suppression (10%), however, occurred only at higher concentrations (200-400 microM). Gliomaneuronal co-culturing resulted in significant neuronal damage and… CONTINUE READING