Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB.

@article{Lee2004TetramethoxyHP,
  title={Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB.},
  author={Hee-Gu Lee and Hyoson Kim and Won Keun Oh and Kyung-Ae Yu and Yong-Kyung Choe and J Ahn and D W Kim and Soo-Hyun Kim and Charles A Dinarello and Kilhyoun Kim and Do-Young Yoon},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1030},
  pages={555-68}
}
Artemisia has been traditionally used in Korean herbal medicine to clear damp heat and to treat uteritis and jaundice. Flavonoids isolated from Artemisia are also known to possess anti-inflammatory activities. In this study, 5,6,3',5'-tetramethoxy 7,4'-hydroxyflavone (p7F) was isolated from Artemisia absinthium. We examined in vitro and in vivo regulatory functions of p7F on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha) as well as… CONTINUE READING
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