Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.

@article{Modesti2003TetramerizationAD,
  title={Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive.},
  author={Mauro Modesti and Murray S. Junop and Rodolfo Ghirlando and Mandy van de Rakt and Martin Gellert and Wei Yang and Roland Kanaar},
  journal={Journal of molecular biology},
  year={2003},
  volume={334 2},
  pages={215-28}
}
The XRCC4 protein is of critical importance for the repair of broken chromosomal DNA by non-homologous end joining (NHEJ). The absence of XRCC4 abolishes chromosomal NHEJ almost completely. One reason for this severe phenotype is that XRCC4 binds and modulates the stability and activity of the NHEJ-specific ligase, DNA ligase IV. XRCC4 in solution is in equilibrium between the dimeric and tetrameric forms. Previous structural studies have shown that the interface between dimers is located in… CONTINUE READING