Tetrameric cell-surface MHC class I molecules

@article{Krishna1992TetramericCM,
  title={Tetrameric cell-surface MHC class I molecules},
  author={Sudhir Krishna and Philippe Benaroch and S. C. Pillai},
  journal={Nature},
  year={1992},
  volume={357},
  pages={164-167}
}
PURIFIED major histocompatibility complex (MHC) class I molecules have been studied at high resolution by X-ray crystallography1; the structure is a complex of a single heavy chain, β2-microglobulin light chain and a tightly bound peptide moiety. We show here that complete MHC class I molecules are post-translationally assembled into tetramers (made up of four heavy chains and four β2-microglobulin units) and that this tetrameric species is expressed on the cell surface. The multivalent… CONTINUE READING

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