Tetrahydrogestrinone: The discovery of a designer steroid

@article{Malvey2005TetrahydrogestrinoneTD,
  title={Tetrahydrogestrinone: The discovery of a designer steroid},
  author={Todd C. Malvey and Thomas D. Armsey},
  journal={Current Sports Medicine Reports},
  year={2005},
  volume={4},
  pages={227-230}
}
The use of steroids and other pharmaceuticals to gain a competitive edge in athletics has been present in the sports world for a long time. Over the past several years, scientific advances in the detection of sports doping agents and improved collaboration between sports organizations have enhanced the monitoring of fair athletic play. Many have suspected the illegal development of designer steroids by rogue scientists to avoid detection by the standard sports doping drug screen. In 2003, the… 

The Use and Misuse of Testosterone in Sport

Performance-Enhancing Drugs I: Understanding the Basics of Testing for Banned Substances.

The testing standards and analytical techniques underlying the procedures used to identify banned substances in biological samples are reviewed, setting the stage for future summaries of the testing required to establish the use of steroids, stimulants, diuretics, and other prohibited substances.

Enhancement drugs and the athlete.

Enhancement drugs and the athlete.

  • F. BotréA. Pavan
  • Medicine
    Physical medicine and rehabilitation clinics of North America
  • 2009

Dual-color bioluminescent bioreporter for forensic analysis: evidence of androgenic and anti-androgenic activity of illicit drugs

The first forensic application of a straightforward, accurate, and cost-effective bioassay, relying on spectral resolution of the two BL signals, in 96-microwell format is reported, and significant anti-androgenic activity was observed in samples labeled as marijuana and hashish, containing Δ9-tetrahydrocannabinol as major constituent.

A screening method for the detection of synthetic glucocorticosteroids in human urine by liquid chromatography–mass spectrometry based on class-characteristic fragmentation pathways

The proposed liquid chromatographic/tandem mass spectrometric method is suitable for the detection of glucocorticosteroids in urine samples taken for “in competition” sport anti-doping control tests, matching the requirements of the World Anti-Doping Agency (WADA) for accredited anti- doping laboratories.

Protein chips for high-throughput doping screening in athletes

Sport and doping are a contradiction in terms, however, doping abuse in sports has been a serious problem for many years and the advent of protein chip technology may enable the screening of all athletes for any illegal use of drugs.

Roundtable Discussion: Anabolic Androgenic Steroids: Part I

A small number of individuals have suggested that testosterone could offer a potentially powerful ergogenic benefit for athletes through the use of anabolic characteristics of the compound.

References

SHOWING 1-10 OF 10 REFERENCES

DESIGNER STEROID ROCKS SPORTS WORLD

BEFORE MID-OCTOBER, FEW PEOple had heard of the synthetic steroid tetrahydrogestrinone (THG). That changed with the official announcement of the identification of THG and the development of a test

Designer Androgens in Sport: When Too Much Is Never Enough

The recent identification of tetrahydrogestrinone (THG), the first true "designer androgen," as a sports doping agent reflects both an alarmingly sophisticated illicit manufacturing facility and an

Tetrahydrogestrinone: discovery, synthesis, and detection in urine.

Sensitive and specific methods for rapid screening of urine samples by liquid chromatography/tandem mass spectrometry and NMR spectroscopy of underivatized Tetrahydrogestrinone and the combination trimethylsilyl ether-oxime derivative of THG are developed.

Detection of norbolethone, an anabolic steroid never marketed, in athletes' urine.

Norbolethone was identified in two urine samples from one athlete by matching the mass spectra and chromatographic retention times with those of a reference standard, and was unusual because the concentrations of endogenous steroids were exceptionally low.

Anabolic-androgenic steroids and testosterone precursors: ergogenic aids and sport.

This article reviews the recent literature on the use of anabolic-androgenic steroids (AAS) for performance enhancement and describes the changes to hematologic, hepatic, lipid, and hormone profiles as a result of years of steroid use.

Tetrahydrogestrinone is a potent androgen and progestin.

It is demonstrated that THG is a highly potent androgen and progestin in a yeast-based in vitro bioassay system expressing human androgens and progesterone receptors and has no estrogenic activity, antagonism for any of the three steroid receptor classes.

An update on regulatory issues in antidoping programs in sport.

A number of substances and methods currently used in doping present serious challenges to the scientific community, and are described briefly.

Doping by design.

  • S. Ashley
  • Materials Science, Medicine
    Scientific American
  • 2004