Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.

@article{Czeredys2017TetrahydrocarbazolesDE,
  title={Tetrahydrocarbazoles decrease elevated SOCE in medium spiny neurons from transgenic YAC128 mice, a model of Huntington's disease.},
  author={Magdalena Czeredys and Filip Maciąg and Axel Methner and Jacek Kuźnicki},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={483 4},
  pages={1194-1205}
}
Huntington's disease (HD) is a hereditary neurodegenerative disease caused by a polyglutamine expansion within the huntingtin (HTT) gene. One of the cellular functions that is dysregulated in HD is store-operated calcium entry (SOCE), a process in which the depletion of Ca2+ from the endoplasmic reticulum (ER) induces Ca2+ influx from the extracellular space. We detected an enhanced activity of SOC channels in medium spiny neurons (MSNs) from YAC128 mice, a transgenic model of HD, and… CONTINUE READING
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