Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.

@article{Madsen2003TetrahydrobiopterinPS,
  title={Tetrahydrobiopterin precursor sepiapterin provides protection against neurotoxicity of 1-methyl-4-phenylpyridinium in nigral slice cultures.},
  author={Jacob Madsen and P. Jansen and Christian Hesslinger and Morten Meyer and Jens Zimmer and Jan Bert Gramsbergen},
  journal={Journal of neurochemistry},
  year={2003},
  volume={85 1},
  pages={214-23}
}
Complex-I inhibition and oxidative processes have been implicated in the loss of nigral dopamine neurones in Parkinson's disease and the toxicity of MPTP and its metabolite MPP+. Tetrahydrobiopterin, an essential cofactor for tyrosine hydroxylase, may act as an antioxidant in dopaminergic neurones and protects against the toxic consequences of glutathione depletion. Here we studied the effects of manipulating tetrahydrobiopterin levels on MPP+ toxicity in organotypic, rat ventral mesencephalic… CONTINUE READING

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