Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.


BACKGROUND Endothelial cell (EC) survival and regeneration are important determinants of the response to vascular injury that leads to neointimal hyperplasia and accelerated atherosclerosis. Nitric oxide (NO) is a key regulator of EC and endothelial progenitor cell function, but the pathophysiological mechanisms that regulate endothelial NO synthase in… (More)
DOI: 10.1161/CIRCULATIONAHA.112.000249


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Citations per Year

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