Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction

@article{Dhillon2004TetrahydrobiopterinAH,
  title={Tetrahydrobiopterin attenuates homocysteine induced endothelial dysfunction},
  author={B. Dhillon and M. Badiwala and A. Maitland and V. Rao and S. Li and S. Verma},
  journal={Molecular and Cellular Biochemistry},
  year={2004},
  volume={247},
  pages={223-227}
}
Homocysteine is an independent risk factor for atherosclerotic vascular disease. It impairs endothelial function via increasing superoxide production and quenching nitric oxide (NO) release. Tetrahydrobiopterin (BH4) is a critical cofactor that couples nitric oxide synthase and facilitates the production of nitric oxide (vs. superoxide anions). In the first study, the effects of hyperhomocysteinemia (0.1 mM, 3 h) on endothelium-dependent vasorelaxation to ACh and A23187 were examined in… Expand
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