Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction.


Tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide synthases (NOS). This study investigated the effect of increasing BH(4) levels on hypoxia-induced pulmonary vasoconstriction (HPV). Sprague Dawley rats and hph-1 (BH(4) deficient) mice were given BH(4) before and during HPV in an isolated perfused lung preparation. BH(4) inhibited HPV in… (More)
DOI: 10.1183/09031936.00188809


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@article{Francis2010TetrahydrobiopterinAT, title={Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction.}, author={Bahaa N Francis and Martin R Wilkins and Lan Zhao}, journal={The European respiratory journal}, year={2010}, volume={36 2}, pages={323-30} }