Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction.

Abstract

Tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide synthases (NOS). This study investigated the effect of increasing BH(4) levels on hypoxia-induced pulmonary vasoconstriction (HPV). Sprague Dawley rats and hph-1 (BH(4) deficient) mice were given BH(4) before and during HPV in an isolated perfused lung preparation. BH(4) inhibited HPV in… (More)
DOI: 10.1183/09031936.00188809

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@article{Francis2010TetrahydrobiopterinAT, title={Tetrahydrobiopterin and the regulation of hypoxic pulmonary vasoconstriction.}, author={Bahaa N Francis and Martin R Wilkins and Lan Zhao}, journal={The European respiratory journal}, year={2010}, volume={36 2}, pages={323-30} }