Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice

@inproceedings{Abudukadier2013TetrahydrobiopterinHA,
  title={Tetrahydrobiopterin Has a Glucose-Lowering Effect by Suppressing Hepatic Gluconeogenesis in an Endothelial Nitric Oxide Synthase–Dependent Manner in Diabetic Mice},
  author={Abulizi Abudukadier and Yoshihito Fujita and Akio Obara and Akiko Ohashi and Toru Fukushima and Yuichi Sato and Masahito Ogura and Yasuhiko Nakamura and Shimpei Fujimoto and Masaya Hosokawa and Hiroyuki Hasegawa and Nobuya Inagaki},
  booktitle={Diabetes},
  year={2013}
}
Endothelial nitric oxide synthase (eNOS) dysfunction induces insulin resistance and glucose intolerance. Tetrahydrobiopterin (BH4) is an essential cofactor of eNOS that regulates eNOS activity. In the diabetic state, BH4 is oxidized to 7,8-dihydrobiopterin, which leads to eNOS dysfunction owing to eNOS uncoupling. The current study investigates the effects of BH4 on glucose metabolism and insulin sensitivity in diabetic mice. Single administration of BH4 lowered fasting blood glucose levels in… CONTINUE READING
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