Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.

  title={Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.},
  author={Keith M. Channon},
  journal={Trends in cardiovascular medicine},
  volume={14 8},
In vascular disease states such as atherosclerosis and diabetes, endothelial nitric oxide (NO) bioactivity is reduced and oxidative stress is increased, resulting in endothelial dysfunction. Recent studies suggest that changes in the activity and regulation of endothelial NO synthase by its cofactor tetrahydrobiopterin (BH4) is an important contributor to endothelial dysfunction. Pharmacologic studies and more recent insights from genetically modified mouse models have improved the… CONTINUE READING

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