Tetrahydrobiopterin: Efficacy in endogenous depression and Parkinson's disease

@article{Curtius2005TetrahydrobiopterinEI,
  title={Tetrahydrobiopterin: Efficacy in endogenous depression and Parkinson's disease},
  author={H. -Ch. Curtius and H. M{\"u}ldner and Alois Niederwieser},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={55},
  pages={301-308}
}
One patient with agitated, 2 patients with inhibited endogenous depression, and 2 patients with Parkinson's disease were treated with tetrahydrobiopterin (BH4) in single oral doses of 0.9–1 g. Part of the clinical symptoms disappeared in the 2 patients with inhibited endogenous depression after 4–5 hours and the symptoms reappeared approximately 10 hours after the loading. In these two patients urinary free dopamine and serotonin increased from low to high normal values parallel to the clinical… CONTINUE READING

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These observations support the theories that depression may be related to a relative lack of certain biogenic amine neurotransmitters and that Parkinson 's disease is primarily related to the loss of dopamine neurons .
These observations support the theories that depression may be related to a relative lack of certain biogenic amine neurotransmitters and that Parkinson 's disease is primarily related to the loss of dopamine neurons .
In these two patients urinary free dopamine and serotonin increased from low to high normal values parallel to the clinical improvement .
In these two patients urinary free dopamine and serotonin increased from low to high normal values parallel to the clinical improvement .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
Both patients with Parkinson 's disease lost their hypokinesia and rigidity and part of the tremor 4 hours after BH4 for a period of approximately 5 hours .
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