Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus

  title={Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus},
  author={Jie Wu and Guo Zhang Jin},
  journal={Brain Research},
  • Jie Wu, G. Jin
  • Published 14 November 1997
  • Biology
  • Brain Research
Mitochondria and NMDA Receptor-Dependent Toxicity of Berberine Sensitizes Neurons to Glutamate and Rotenone Injury
It is reported that low micromolar berberine causes rapid mitochondria-dependent toxicity in primary neurons characterized by mitochondrial swelling, increased oxidative stress, decreased mitochondrial membrane potential and depletion of ATP content, and the need for further safety assessment is highlighted.
Tetrahydroberberine, an Isoquinoline Alkaloid Isolated from Corydalis Tuber, Enhances Gastrointestinal Motor Function
Oral administration of tetrahydroberberine, with D2 receptor antagonist and 5-HT1A receptor agonist properties, has significant potential as a therapeutic for treatment of FD.
Effect of Berberine on Cell Survival in the Developing Rat Brain Damaged by MK-801
Berberine has neuroprotective effect on damaged neurons and neurodegenerating brains of neonatal animal model induced by MK-801 administration and suggests that berberine promotes activity dependent cell survival mediated by NMDA receptor.
Berberine: Pathways to protect neurons
This review is trying to analyze mechanisms, which actually play roles in neuronal disease models such as brain ischemia, Alzheimer's disease, and experimental autoimmune encephalomyelitis, which provide novel insights into the clinical treatment of neurological disorders.
Berberine protects against glutamate-induced oxidative stress and apoptosis in PC12 and N2a cells
Berberine protects against glutamate-induced PC12 and N2a cells injury by decreasing oxidative stress and subsequently inhibiting apoptosis, relevant to berberine treatment in neurodegenerative disorders, such as dementia (Alzheimer’s disease), seizures, and stroke.
The protective effect of berberine against neuronal damage by inhibiting matrix metalloproteinase-9 and laminin degradation in experimental autoimmune encephalomyelitis
Berberine could provide protection against neuronal damage in EAE by inhibiting gelatinase activity and reducing laminin degradation, providing further support that berberine can be a potential therapeutic agent for multiple sclerosis.
Phytochemical variation in Canadian Hydrastis canadensis L (goldenseal) and the in vitro inhibition of human cytochrome P450-mediated drug metabolism by H canadensis and other botanicals
Berberine concentration was a significant factor in CYP3A4 and CYP19 inhibition, and Comparisons with cultivated material showed no difference in alkaloid content, thus the medicinal value of cultivated material is not likely increased with addition of wild plants.


Release of intracellular calcium and modulation of membrane currents by caffeine in bull‐frog sympathetic neurones.
The results suggest that caffeine increases intracellular calcium by sensitizing calcium‐induced calcium release and that the evoked increase in [Ca2+]i is predominantly buffered by a Ruthenium Red‐sensitive sequestration process which is not mitochondrial.
Strychnine‐induced potassium current in CA1 pyramidal neurones of the rat hippocampus
The results suggest that the GTP binding proteins are involved in the Str‐induced IK, a response to the dissociated hippocampal CA1 neurones of the rat investigated with the whole‐cell mode of the patch‐clamp technique.
Tetrahydroprotoberberine--a new chemical type of antagonist of dopamine receptors.
It is suggested that THPB is a new chemical type of antagonist of brain DA-receptors, and its effect was more potent than that of THB and l-THP.
Antifibrillatory effect of tetrahydroberberine.
  • A. Y. Sun, D. X. Li
  • Chemistry, Biology
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1993
The results indicated that THB had an potent antifibrillatory effect, which might be attributed to its blockade of potassium, calcium, and sodium currents.
[Effect of (-)-stepholidine on blood pressure and alpha-adrenoceptor agonists-, KCl- and CaCl2-evoked contractions of aortic strips].
The results suggest that (-)-SPD stimulated mainly the alpha 2-adrenergic receptors of presynaptic nerve endings in rat and rabbit aortic strips and blocked the voltage-dependent Ca2+ channel.
Dopaminergic unique affinity of tetrahydroberberine and l-tetrahydroberberine-d-camphor sulfonate.
The data suggest that THB and THB-CS have a central depressant effect through both D1 and D2 dopaminergic receptors and may have different modes of action from that of standard neuroleptics.
Effects of (-)-stepholidine and tetrahydroberberine on high potassium-evoked contraction and calcium influx in rat artery.
The results showed that the effective concentrations of the 2 drugs inhibiting high KCl-induced contraction and 45Ca transmembrane influx in rat thoracic aorta were at a similar level, and that they were nearly 1/100 and 1/10 of those of verapamil respectively, indicating that (-)-SPD and THB had similar calcium channel blocking effect on rat artery, but were weaker than verapamsil.