Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta

  title={Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta},
  author={Chen Wu and Kechun Yang and Qiang Liu and Matoko Wakui and Guo Zhang Jin and Xuechu Zhen and Jie Wu},

Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.

The data indicate that the energy states caused by various doses of rotenone could significantly influence the opening states of KATP channels, and long-term energy stress may raise the opening rate and opening sensitivity of this channel.

The inhibitory effects of levo‐tetrahydropalmatine on rat Kv1.5 channels expressed in HEK293 cells

K(ATP) channel block prevents proteasome inhibitor-induced apoptosis in differentiated PC12 cells.

Nicotinic Modulation of GABAA Receptor Function in Single Dopaminergic Neurons Freshly-Dissociated from Rat Substantia Nigra Pars Compacta

The results suggest that nicotine directly boosts the function of postsynaptic GABAA receptors, which in turn results in hyperpolarization and reduced excitability of putative SNc DAergic neurons through novel α4β2-nAChR-dependent pathways and/or additional post synaptic mechanisms.

Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells.

It is demonstrated that l-THP blocks neuronal α4β2-nAChR function, which may underlie its inhibition on nicotine addiction, which is explored as anti-addiction treatments for drug abuse including nicotine.

A preclinical assessment of d.l-govadine as a potential antipsychotic and cognitive enhancer.

Data provide the first evidence that d.l-Gov may have antipsychotic properties in conjunction with pro-cognitive effects, lending further support to the hypothesis that THPBs are a class of compounds which merit serious consideration as novel treatments for schizophrenia.



Iptakalim Modulates ATP-Sensitive K+ Channels in Dopamine Neurons from Rat Substantia Nigra Pars Compacta

  • Jie WuJun Hu M. Wakui
  • Biology, Chemistry
    Journal of Pharmacology and Experimental Therapeutics
  • 2006
iptakalim is not a KATP channel opener in rat SNc DA neurons; instead, iptakAlim is a pm-KatP channel closer at high concentrations, which stimulates further pharmacological investigation and the development of possible therapeutic applications.

Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta

Results highlight KATP channels as possible relevant targets of Memantine effects in the brain and suggest another mechanism of action underlying the protective role of memantine in Parkinson's disease.

K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons

It is shown that in response to parkinsonism-inducing toxins, electrophysiological activity of SN neurons, but not VTA DA neurons, is lost owing to activation of K-ATP channels.

Electrophysiological, Pharmacological, and Molecular Evidence for α7-Nicotinic Acetylcholine Receptors in Rat Midbrain Dopamine Neurons

Electrophysiological, pharmacological, and molecular evidence indicates that nAChR α7 subunits and functional α7-nAChRs are expressed somatodendritically by midbrain DA neurons, where they may play important physiological roles and contribute to nicotine reinforcement and dependence.

Dopamine-induced ionic currents in acutely dissociated rat neurons of CNS.

  • J. WuP. ChenG. Jin
  • Biology, Chemistry
    Zhongguo yao li xue bao = Acta pharmacologica Sinica
  • 1996
The results suggest that DA-induced outward current is carried by K+ in single hippocampal CA1 pyramidal neuron.

Rescue of Mesencephalic Dopaminergic Neurons in Culture by Low-Level Stimulation of Voltage-Gated Sodium Channels

It is shown that DA cell loss can be prevented efficiently by low concentrations of the Na+ channel agonist veratridine, and this results support the idea that mesencephalic DA neurons depend primarily on excitatory input for their survival during development.

Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids

The properties of these 2 cell types broadly correspond with those described by electrophysiological studies in vivo, in which case the majority, or principal, cells are believed to be dopaminergic.