Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta

@article{Wu2010TetrahydroberberineBA,
  title={Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta},
  author={Chen Wu and Kechun Yang and Qiang Liu and Matoko Wakui and Guo Zhang Jin and Xuechu Zhen and Jie Wu},
  journal={Neuropharmacology},
  year={2010},
  volume={59},
  pages={567-572}
}
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27 Citations
Background Citations
9
Methods Citations
1
Results Citations
1

27 Citations

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Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase.
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The data indicate that the energy states caused by various doses of rotenone could significantly influence the opening states of KATP channels, and long-term energy stress may raise the opening rate and opening sensitivity of this channel.
The inhibitory effects of levo‐tetrahydropalmatine on rat Kv1.5 channels expressed in HEK293 cells
The role of KATP channel blockade and activation in the protection against neurodegeneration in the rotenone model of Parkinson's disease.
K(ATP) channel block prevents proteasome inhibitor-induced apoptosis in differentiated PC12 cells.
Nicotinic Modulation of GABAA Receptor Function in Single Dopaminergic Neurons Freshly-Dissociated from Rat Substantia Nigra Pars Compacta
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The results suggest that nicotine directly boosts the function of postsynaptic GABAA receptors, which in turn results in hyperpolarization and reduced excitability of putative SNc DAergic neurons through novel α4β2-nAChR-dependent pathways and/or additional post synaptic mechanisms.
Levo-tetrahydropalmatine inhibits α4β2 nicotinic receptor response to nicotine in cultured SH-EP1 cells.
TLDR
It is demonstrated that l-THP blocks neuronal α4β2-nAChR function, which may underlie its inhibition on nicotine addiction, which is explored as anti-addiction treatments for drug abuse including nicotine.
Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson's disease
Demethylenetetrahydroberberine protects dopaminergic neurons in a mouse model of Parkinson's disease.
A preclinical assessment of d.l-govadine as a potential antipsychotic and cognitive enhancer.
TLDR
Data provide the first evidence that d.l-Gov may have antipsychotic properties in conjunction with pro-cognitive effects, lending further support to the hypothesis that THPBs are a class of compounds which merit serious consideration as novel treatments for schizophrenia.
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References

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TLDR
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Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
TLDR
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Tetrahydroberberine inhibits acetylcholine-induced K+ current in acutely dissociated rat hippocampal CA1 pyramidal neurons
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TLDR
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