Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta
@article{Wu2010TetrahydroberberineBA, title={Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta}, author={Chen Wu and Kechun Yang and Qiang Liu and Matoko Wakui and Guo Zhang Jin and Xuechu Zhen and Jie Wu}, journal={Neuropharmacology}, year={2010}, volume={59}, pages={567-572} }
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References
SHOWING 1-10 OF 37 REFERENCES
Iptakalim Modulates ATP-Sensitive K+ Channels in Dopamine Neurons from Rat Substantia Nigra Pars Compacta
- Biology, ChemistryJournal of Pharmacology and Experimental Therapeutics
- 2006
iptakalim is not a KATP channel opener in rat SNc DA neurons; instead, iptakAlim is a pm-KatP channel closer at high concentrations, which stimulates further pharmacological investigation and the development of possible therapeutic applications.
Memantine Inhibits ATP-Dependent K+ Conductances in Dopamine Neurons of the Rat Substantia Nigra Pars Compacta
- BiologyJournal of Pharmacology and Experimental Therapeutics
- 2007
Results highlight KATP channels as possible relevant targets of Memantine effects in the brain and suggest another mechanism of action underlying the protective role of memantine in Parkinson's disease.
Tetrahydroberberine inhibits acetylcholine-induced K+ current in acutely dissociated rat hippocampal CA1 pyramidal neurons
- Biology, ChemistryNeuroscience Letters
- 1997
K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons
- BiologyNature Neuroscience
- 2005
It is shown that in response to parkinsonism-inducing toxins, electrophysiological activity of SN neurons, but not VTA DA neurons, is lost owing to activation of K-ATP channels.
Tetrahydroberberine suppresses dopamine-induced potassium current in acutely dissociated CA1 pyramidal neurons from rat hippocampus
- BiologyNeuroscience Letters
- 1996
Tetrahydroberberine blocks membrane K+ channels underlying its inhibition of intracellular message-mediated outward currents in acutely dissociated CA1 neurons from rat hippocampus
- BiologyBrain Research
- 1997
Electrophysiological, Pharmacological, and Molecular Evidence for α7-Nicotinic Acetylcholine Receptors in Rat Midbrain Dopamine Neurons
- Biology, ChemistryJournal of Pharmacology and Experimental Therapeutics
- 2004
Electrophysiological, pharmacological, and molecular evidence indicates that nAChR α7 subunits and functional α7-nAChRs are expressed somatodendritically by midbrain DA neurons, where they may play important physiological roles and contribute to nicotine reinforcement and dependence.
Dopamine-induced ionic currents in acutely dissociated rat neurons of CNS.
- Biology, ChemistryZhongguo yao li xue bao = Acta pharmacologica Sinica
- 1996
The results suggest that DA-induced outward current is carried by K+ in single hippocampal CA1 pyramidal neuron.
Rescue of Mesencephalic Dopaminergic Neurons in Culture by Low-Level Stimulation of Voltage-Gated Sodium Channels
- BiologyThe Journal of Neuroscience
- 2004
It is shown that DA cell loss can be prevented efficiently by low concentrations of the Na+ channel agonist veratridine, and this results support the idea that mesencephalic DA neurons depend primarily on excitatory input for their survival during development.
Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1989
The properties of these 2 cell types broadly correspond with those described by electrophysiological studies in vivo, in which case the majority, or principal, cells are believed to be dopaminergic.