Tetrahydroaminoacridine-induced ribosomal changes and inhibition of protein synthesis in rat hepatocyte suspensions.

@article{Fariss1994TetrahydroaminoacridineinducedRC,
  title={Tetrahydroaminoacridine-induced ribosomal changes and inhibition of protein synthesis in rat hepatocyte suspensions.},
  author={Marc Wise Fariss and Svend Aage Johnsen and Lloyd P. Walton and Virgil R. Mumaw and Sidhartha D. Ray},
  journal={Hepatology},
  year={1994},
  volume={20 1 Pt 1},
  pages={
          240-6
        }
}
Tacrine (tetrahydroaminoacridine) is currently the only drug approved for the treatment of Alzheimer's disease. Unfortunately, tetrahydroaminoacridine therapy is often limited by this drug's propensity to induce reversible hepatotoxicity. Using suspensions of freshly isolated rat hepatocytes, we investigated the mechanism of tetrahydroaminoacridine cytotoxicity by examining the effect of tetrahydroaminoacridine on hepatocyte viability, protein synthesis, protein, DNA and RNA levels and… CONTINUE READING
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