Tetrahydroaminoacridine and other allosteric antagonists of hippocampal M1 muscarine receptors.

@article{Potter1989TetrahydroaminoacridineAO,
  title={Tetrahydroaminoacridine and other allosteric antagonists of hippocampal M1 muscarine receptors.},
  author={Lincoln T. Potter and Cynthia A. Ferrendelli and Helene E. Hanchett and Michael A Hollifield and Matthew V Lorenzi},
  journal={Molecular pharmacology},
  year={1989},
  volume={35 5},
  pages={652-60}
}
Tetrahydroaminoacridine (THA) and a variety of other nonclassical antagonists of muscarine receptors were studied for their ability to bind to primary and allosteric sites on muscarine receptors in rabbit hippocampal membranes. Competition curves between 13 antagonists and 1 nM [3H]pirenzepine (Kd = 3 nM) were simple mass action curves, but THA produced steeper curves, indicating positive cooperativity. Nonetheless, THA inhibited the binding of low concentrations of [3H]pirenzepine, [3H]N… CONTINUE READING

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