Tetrahexylammonium ions increase Ca2+ sensitivity of contraction of guinea-pig ileal smooth muscle

Effects of tetraalkylammonium ions, having tetraalkyl chains of increasing length from ethyl to octyl, on inositol-trisphosphate (InsP 3)-induced Ca2+ release and contractile mechanics were examined in guinea-pig skinned ileal smooth muscle longitudinal strips. Although tetrahexylammonium ions (THexA) appeared to be the most potent inhibitor of Ca2+ release… CONTINUE READING