Tetradian oscillation of estrogen receptor α is necessary to prevent liver lipid deposition.


In the liver of female mice, the transcriptional activity of estrogen receptor (ER) α oscillates in phase with the 4-d-long estrous cycle. Here systemic, genome-wide analysis demonstrates that ER tetradian oscillation is necessary to generate pulses of expression in genes for fatty acid and cholesterol synthesis. This ER-dependent metabolic programming… (More)
DOI: 10.1073/pnas.1205797109