Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.

  title={Tetracyclines inhibit connective tissue breakdown by multiple non-antimicrobial mechanisms.},
  author={Lorne M. Golub and Hyun Moo Lee and Maria Emanuel Ryan and William V Giannobile and Johanna Payne and Timo Sorsa},
  journal={Advances in dental research},
  volume={12 2},
A seminal experiment involving a germ-free rat model of connective tissue breakdown (followed soon thereafter by a series of in vitro studies) identified an unexpected non-antimicrobial property of tetracyclines (TCs). This ability of TCs to inhibit matrix metalloproteinases (MMPs) such as collagenase was found to reflect multiple direct and indirect mechanisms of action, and to be therapeutically useful in a variety of dental (e.g., adult periodontitis) and medical (e.g., arthritis… CONTINUE READING
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