Tetracyclines induce apoptosis in osteoclasts.

  title={Tetracyclines induce apoptosis in osteoclasts.},
  author={J T Bettany and Nicola M Peet and R. G. Wolowacz and Timothy M. Skerry and Peter S. Grabowski},
  volume={27 1},
Chemically modified tetracyclines (CMTs) are thought to inhibit bone resorption through inhibition of matrix metalloproteinases. Here we report that some tetracyclines also induce apoptosis in rabbit osteoclasts and inhibit differentiation and activity of osteoclasts in murine osteoblast/marrow cocultures. Apoptosis of mature rabbit osteoclasts increased from 5.5 +/- 1.4% (mean +/- SD) in control cultures to 44.9 +/- 6.3% (p < 0.001) and 18.9 +/- 4.0% (p < 0.005) with CMT-3 and doxycycline (10… CONTINUE READING


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